Identifying strategic pillars and potential development scenarios for the Slovak healthcare system by 2045. The aim is to examine how experts, healthcare professionals, managers, and innovation stakeholders perceive future system challenges and the opportunities offered by digitalisation, prevention, and emerging technologies. The research applies a mixed-methods design, combining a quantitative survey (N = 125) with qualitative analysis of three types of interviews, using thematic analysis to extract core patterns. The study also includes a comparison with the Estonian healthcare model, internationally recognized for its advanced digital ecosystem. The final output is the strategic framework "Healthcare 2045," defining five key pillars for system transformation: prevention, digital integration, innovation and AI, workforce development, and sustainable financing.